John Henson on the Mike Calta Show Henson began his career as a stand-up comic. After appearing in films in the 90's, he became the longest-running host (four years) of Talk Soup on the E! Entertainment Network. From 2008 to 2014, Henson co-hosted the ABC obstacle course game-show, Wipeout, and always ended the show with the catch phrase, "Good night, and Big Balls"